Journal
CARBOHYDRATE POLYMERS
Volume 94, Issue 1, Pages 634-641Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.01.091
Keywords
Hyaluronic acid; Niosome; Transdermal; Tumor therapy
Categories
Funding
- NSFC [31240007, 81271727]
- Shandong Youth Scientist Awards Foundation [BS2012SW024]
Ask authors/readers for more resources
To develop a functional nanosized transdermal drug delivery system for tumor therapy, amphiphilic hyaluronic acid (HA) based niosome was constructed combining transdermal and tumor targeting ability in one entity. HA esterified with monostearin, the conjugate labeled as HA-GMS self-assembled onto niosome surface and formed HA-niosome. The multilayer vesicle had small size (around 40 nm), good stability and desirable drug encapsulating efficacy, and well compatible with blood. It exhibited better endocytosis to mouse breast tumor cell (4T1) than the control chitosan nanoparticle, which was verified qualitatively and quantitatively. Skin permeation of HA-niosome was proven to be efficient using in vitro stratum corneum model and in vivo fluorescence observation. Histological section study confirmed the security and efficiency of transdermal permeation. The results evidence HA-niosome to be exciting and promising for tumor therapy through trandermal administration. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available