Journal
CARBOHYDRATE POLYMERS
Volume 96, Issue 2, Pages 495-502Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.04.006
Keywords
Chitosan; Ferulic acid; Grafting; Antioxidant property; Water-soluble chitosan
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Funding
- Thailand Research Fund (TRF) through the Royal Golden Jubilee Ph.D. program [PHD/0050/2553]
- Commission on Higher Education, Ministry of Education, Thailand (National Research University of Thailand)
- National Science and Technology Development Agency (NSTDA), Thailand
- NSTDA
- Crown Property Bureau
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The objective of the present work was to improve the antioxidant activity and water solubility of chitosan by grafting with ferulic acid through a carbodiimide-mediated coupling reaction. UV-vis spectrophotometry, FTIR, H-1 NMR and ninhydrin assay confirmed the grafting of ferulic acid onto chitosan at the C-2 position. Ferulic acid grafted chitosan - prepared using a mole ratio of chitosan to ferulic acid of 1:1, reaction temperature of 60 degrees C, and reaction time of 3 h - possessed the highest ferulic acid substitution degree, i.e. 0.37. Although ferulic acid grafted chitosan showed reduced crystallinity (similar to 10%) and decreased decomposition temperature (similar to 55 degrees C) as compared to chitosan, it exhibited greater radical scavenging activity (similar to 55%) and was soluble in water (up to 1.3 mg/mL). The improved antioxidant property and water solubility of this chitosan derivative could open a wide range of applications, particularly its use as an antioxidant in food, food packaging, biomedical, pharmaceutical and cosmetics industries. (C) 2013 Elsevier Ltd. All rights reserved.
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