Journal
CARBOHYDRATE POLYMERS
Volume 92, Issue 1, Pages 856-864Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.10.005
Keywords
Chitosan conjugates; Controlled release; Self-assembled nanoparticles; Tocopherol
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Funding
- Erasmus Mundus Animo-Chevere
- Complutense University (Madrid, Spain)
- Santander Group
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Synthetic 06-succinylated chitosan and commercial glycol chitosan were covalently linked to DL-alpha-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254-496 nm mean diameters and DL-alpha-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40-75 nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7 h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation. (C) 2012 Elsevier Ltd. All rights reserved.
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