Journal
CARBOHYDRATE POLYMERS
Volume 90, Issue 2, Pages 870-874Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.06.013
Keywords
Inonotus obliquus; Polysaccharides; Purification; Antitumor; Immunomodulatory
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Funding
- State Key Laboratory of Dairy Biotechnology, Bright Dairy Food Co. Ltd. [SKLDB2011-002]
- National Natural Science Foundation of China [31101361]
- Research Fund of National 12th Five-Year Plan of China [2011AA100806-3]
- Fundamental Research Funds for the Central Universities [JUSRP211A30]
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The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-alpha. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity. (C) 2012 Elsevier Ltd. All rights reserved.
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