Journal
CARBOHYDRATE POLYMERS
Volume 90, Issue 3, Pages 1378-1385Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.07.007
Keywords
Hyaluronan; Poly(N-isopropylacrylamide); Stimuli responsive hydrogel
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Funding
- European Union [NMP3-SL-2010-245993]
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An efficient and scale-up ready single-step synthesis for the conjugation of thermoresponsive polymers to hyaluronic acid (HA) was established. Jeffamines (R) (JFM) and poly(N-isopropylacrylamide) (PNIPAM) were grafted to HA via direct amidation mediated by 1,1'-carbonyldiimidazole activation. The temperature-induced gelation of the semi-synthetic co-polymers was characterized by rheology as a function of the temperature and by differential scanning calorimetry (DSC). A HA-JFM conjugate with sol-gel transition in a physiologically relevant temperature range was identified. The grafting of PNIPAM resulted in the drastic change of the main rheological properties of native HA, revealing the hydrophobic non-covalent nature of the interactions between the thermoresponsive brushes in the gel state. Owing to the reversibility of these interactions and the sharpness of the transition, the HA-PNIPAM conjugates are suitable candidates for the incorporation of drugs, cells or ceramic materials for different biomedical applications. (C) 2012 Elsevier Ltd. All rights reserved.
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