Journal
CARBOHYDRATE POLYMERS
Volume 87, Issue 1, Pages 737-743Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.08.055
Keywords
Sodium alginate; Electrospinning; Core-shell; Nanofibers; Tissue engineering
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Funding
- Natural Science Foundation of Jiangsu Province [BY2009121]
- State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
- Changzhou Microelectronics Chemical Material Public Technology Platform [CZ2010003]
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Core-shell structure nanofibers of sodium alginate/poly(ethylene oxide) were prepared via electrospinning their dispersions in water solution. The core-shell structure morphology of the obtained nanofibers was viewed under scanning electron microscope (SEM) and transmission electron microscope (TEM), and X-ray photoelectron spectroscopy (XPS) analysis was used to further quantify the chemical composition of the core-shell composite SA/PEO nanofibers surface in detail. Furthermore, one-step cross-linking method through being immersed in CaCl2 solution was investigated to improve the anti-water property of the electrospun nanofibers mats in order to facilitate their practical applications as tissue engineering scaffolds, and the changes of the structural of nanofibers before and after cross-linking was characterized by Fourier transform infrared (FT-IR). Indirect cytotoxicity assessment indicated that SA/PEO nanofibers membrane was nontoxic to the fibroblasts cells, and cell culture suggested that SA/PEO nanofibers tended to promote fibroblasts cells attachment and proliferation. It was assumed that the nanofibers membrane of electrospun SA/PEO could be used for tissue engineering scaffolds. (C) 2011 Published by Elsevier Ltd.
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