Journal
CARBOHYDRATE POLYMERS
Volume 89, Issue 1, Pages 72-79Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.02.051
Keywords
Biodistribution; Brain targeting; Chitosan; Confocal microscopy; Intranasal route; Venlafaxine
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Funding
- All India Council for Technical Education (AICTE) Government of India
- Department of Science and Technology (DST), New Delhi
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The purpose of the present investigation was to prepare venlafaxine (VLF) loaded chitosan nanoparticles (NPs) to enhance the uptake of VLF to brain via intranasal (in.) delivery. VLF loaded chitosan NPs were prepared and characterized for particle size, size distribution, zeta potential, encapsulation efficiency and in vitro drug release. In order to investigate the localization of chitosan NPs in brain and other organs qualitatively confocal laser scanning microscopy technique was carried out using rhodamine-123 (ROD-123) as marker. The levels of VLF in plasma and brain tissues were also determined, the brain/blood ratios of VLF for VLF (i.v.), VLF (i.n.), VLF chitosan NPs (in.) were 0.0293, 0.0700 and 0.1612, respectively, at 0.5 h, indicative of better brain uptake of VLF chitosan NPs. The higher drug transport efficiency (508.59) and direct transport percentage (80.34) of VLF chitosan NPs as compared to other formulations suggest its better efficacy in treatment of depression. (C) 2012 Elsevier Ltd. All rights reserved.
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