Journal
CARBOHYDRATE POLYMERS
Volume 87, Issue 1, Pages 581-588Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.08.024
Keywords
Chitosan/gelatin complexes; Buccal delivery; Mucoadhesive films; Propranolol hydrochloride
Categories
Ask authors/readers for more resources
The aim of this work was to develop and characterize chitosan/gelatin films as innovative mucoadhesive system for buccal delivery of propranolol hydrochloride. FT-IR and TGA analysis confirmed the interaction between chitosan and gelatin. The presence of higher chitosan amounts in chitosan/gelatin films allowed the lowest percent water-uptake ability (235.1 +/- 5.3%) and the highest in vivo residence time in the buccal cavity (240 +/- 13 min). Moreover, the presence of mannitol in the formulation allowed 80% drug permeation through porcine buccal mucosa in 5 h. This behaviour suggests that the application of four and two films containing 5 mg of propranolol hydrochloride could be suitable for achieving the proposed daily dose for hypertension and atrial fibrillation treatment, respectively. Another interesting aspect of chitosan/gelatin films was their compatibility with buccal microflora in the absence of drug and their ability to determine growth inhibition for pathogen bacteria, but not for probiotic species, when loaded with drug. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available