Journal
CARBOHYDRATE POLYMERS
Volume 89, Issue 1, Pages 124-131Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.02.060
Keywords
Atom transfer radical polymerization; pH-sensitivity; Glucose-sensitivity; Insulin release
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Funding
- National Science Foundation of China [20804021, 51173085]
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Amphiphilic poly(acrylic acid-co-acrylamidophenylboronic acid)-block-poly(2-acryloxyethyl galactose)block-poly(acrylic acid-co-acrylamidophenylboronic acid) (((PAA-co-PAAPBA)-b-)(2) PAEG) copolymer was fabricated: The poly(2-acryloyloxyethyl pentaacetylgalactoside)(PAEAcG) with narrow molecular weight distributions (M-w/M-n <= 1.22) was prepared by atom transfer radical polymerization (ATRP) using dibromo-p-xylene (DBX) as initiator. Then the well-defined triblock copolymer poly(t-butyl acrylate)-b-poly(2-acryloyloxyethyl pentaacetylgalactoside)-b-poly(t-butyl acrylate) (PtBA-b-PAEAcG-b-PtBA) was synthesized by ATRP of tBA using PAEAcG homopolymer with dibromo end groups as macroinitiator. After hydrolysis of t-butyl acrylate block, amide linkage and deacetylation, the final copolymer ((PAA-co-PAAPBA)-b-)(2)PAEG was obtained. Because of characteristics of three different segments, amphiphilic ((PAA-co-PAAPBA)-b-)(2)PAEG can self-assemble into pH- and glucose-responsive nanoparticles studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Furthermore, the in vitro release profiles of insulin also revealed obvious pH- and glucose-sensitivity of the nanoparticles. The analysis of cell viability suggested that the copolymer nanoparticles had good cytocompatibility. (C) 2012 Elsevier Ltd. All rights reserved.
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