Journal
CARBOHYDRATE POLYMERS
Volume 87, Issue 3, Pages 2327-2331Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.10.068
Keywords
Acanthopanax senticosus; Polysaccharide; Diabetes; Hypoglycemic; Hypolipidemic
Categories
Funding
- National Natural Science Foundation of China [81101736]
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One water-soluble polysaccharide ASP was purified from Acanthopanax senticosus and its physicochemical properties were confirmed by the combination of chemical and instrumental analysis. ASP administered orally at three doses (100, 200 and 400 mg/kg body weight) could significantly decrease the concentration of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) cholesterol levels except for high density lipoprotein (HDL) cholesterol level and the relative ratio (HDL/TC) in alloxan-induced diabetic mice, compared with the diabetic controls without drug treatment, comparable with that of diabetic mice treated with metformin. Furthermore, ASP could obviously increase the body weight and serum insulin level and reduce the fasting blood glucose (FBG) levels, especially at dose of 200 mg/kg. The data demonstrated ASP at the certain did often exhibit the optimal protective effect in alloxan-induced diabetic mice. It is promising that ASP may serve as a drug candidate or a healthcare food for diabetic therapy or protection. (C) 2011 Elsevier Ltd. All rights reserved.
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