Journal
CARBOHYDRATE POLYMERS
Volume 87, Issue 1, Pages 862-868Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.08.082
Keywords
Sea cucumber; Fucosylated chondroitin sulfate; Sulfated fucose; Anticoagulant activity
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Funding
- Yunnan Provincial Science and Technology Department in China [2010CI116]
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Fucosylated chondroitin sulfate (FuCS) is a glycosaminoglycan from sea cucumber, made up of alternating beta-D-glucuronic acid and N-acetyl-beta-D-galactosamine units. The beta-D-glucuronic acid residues have branches of sulfated fucose, while the fucose branches may have distinguishable patterns and proportions of sulfate substitution. The structure of the sulfated fucose branches of the fucosylated chondroitin sulfate from the sea cucumber Thelenata ananas has been characterized by mild acid hydrolysis and NMR technology. The results showed that the fucose residues are made up of 3-,4-mono-O-sulfated fucose and 2,4-di-O-sulfated fucose with about 25:22:53, respectively. The sulfated fucose branches are essential for the anticoagulant action of FuCS, and this potent effect is possibly related to the occurrence of 2,4-di-O-sulfated fucose units. Furthermore, these branches could constitute the structural requirement for the binding of the glycosaminoglycan to coagulant enzymes, such as thrombin by HCII, factor X by the intrinsic tenase complex. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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