Journal
SPECTROSCOPY-AN INTERNATIONAL JOURNAL
Volume 19, Issue 5-6, Pages 259-266Publisher
IOS PRESS
DOI: 10.1155/2005/258617
Keywords
hypocrellin B; MCHB; CT-DNA; intercalation mechanism; circular dichroism spectroscopy; fluorescence spectroscopy; anticancer drugs
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The interaction of anticancer drug hypocrellin B (HB) and mono-cysteine substituted hypocrellin B (MCHB) with calf thymus deoxyribonucleic acid (CT-DNA) has been investigated using spectral methods. The results of UV-visible spectra showed that the HB and MCHB can intercalate into the base-stacking domain of the CT-DNA double helix. Further studies based on fluorescence spectroscopy and circular dichroism (CD) spectroscopy also supported the intercalation mechanism.
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