Journal
CARBOHYDRATE POLYMERS
Volume 89, Issue 3, Pages 795-801Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.04.013
Keywords
Microcapsules; Chitosan; Miconazole; Clotrimazole; Control-release
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Funding
- Innovation Technology Fund Hong Kong [ITS/417/09]
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In this paper, a simple and versatile coacervation technique has been developed by using an ultrasound-assisted oil/water emulsion method for the preparation of antifungal agent-loaded microcapsules. Two types of chitosan microcapsules are successfully prepared. The mean particle size of the chitosan/miconazole nitrate microcapsules is 2.6 mu m and that of the chitosan/clotrimazole microcapsules is 4.1 mu m. The encapsulation efficiency of the chitosan/miconazole nitrate microcapsules (77.58-96.81%) is relatively higher than that of the chitosan/clotrimazole microcapsules (56.66-93.82%). The in vitro drug release performance of the microcapsules shows that the chitosan/miconazole nitrate microcapsules release about 49.5% of the drug while chitosan/clotrimazole microcapsules release more than 66.1% of the drug after 1211 under a pressure 015 kg at pH 5.5, which is similar to the pH of human skin. The prepared drug-loaded microcapsules could be applied onto bandages or socks, and will continuously release antifungal drugs in a controlled manner under pressure. (C) 2012 Elsevier Ltd. All rights reserved.
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