Journal
CARBOHYDRATE POLYMERS
Volume 87, Issue 3, Pages 2231-2236Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.10.051
Keywords
Low molecular weight (LMW) chitosan; beta-Chitin; Antioxidant; Bile acid; Squid pens
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Funding
- Science and Technology Department of Zhejiang Province of the People's Republic of China [2008C14067]
- National Natural Science Foundation of China [20876143, 21176220]
- Ministry of Education of China [200803350039]
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Chitosans were prepared by H2O2 oxidative depolyrnerization from squid pens with low molecular weights (LMW) of 13,025, 7011, 4169, 2242 and 963 Da. The bile acid binding capacities and antioxidant properties of LMW chitosans were studied in vitro. LMW chitosans exhibited stronger bile acid binding capacities than that of chitosan. The scavenging ability of LMW chitosans against DPPH radicals improved with increasing concentration, and EC50 values were below 1.3 mg/mL. The EC50 values of LMW chitosans against hydroxyl radicals ranged from 0.93 to 3.66 mg/mL. All LMW chitosans exhibited a strong ferrous ion chelating effect and reducing power. At 1 mg/mL, the scavenging ability of chitosan-963 towards superoxide radicals was 67.76%. These results indicated that LMW chitosans which have stronger bile acid binding capacity and antioxidant activities may act as potential antioxidants in vitro. (C) 2011 Elsevier Ltd. All rights reserved.
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