Journal
CARBOHYDRATE POLYMERS
Volume 85, Issue 4, Pages 869-874Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.04.011
Keywords
N-alpha-glutaric acid chitosan; Alginate; pH-sensitive hydrogel; Bovine serum albumin; Oral delivery
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Funding
- Natural Science Foundation of Anhui Education Bureau
- Key Laboratory of Bioresource Protection and Utilization of Anhui Province
- Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province
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A novel pH-sensitive hydrogel based on dual crosslinked alginate/N-alpha-glutaric acid chitosan (GAC) was prepared. The homogeneous alginate/GAC solution was dropped into calcium chloride solution and crosslinked by Ca2+ ions. Sequentially, the crosslinked beads were suspended in sodium sulfate solution for forming dual crosslinked beads. The swelling behaviors of dual crosslinked beads were investigated in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). Bovine serum albumin (BSA) was loaded in beads with the high loading efficiency. The sustained release profiles of BSA loaded beads were studied at different pH environment for simulating gastrointestinal condition. The amount of BSA released from the beads at pH 1.2 was relatively low (below 18%), while almost 100% of BSA could be released at pH 7.4. The preliminary results clearly suggested that the dual crosslinked alginate/GAC hydrogel may be a potential polymeric carrier for oral delivery of protein drugs. (C) 2011 Elsevier Ltd. All rights reserved.
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