Journal
CARBOHYDRATE POLYMERS
Volume 86, Issue 2, Pages 666-671Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.05.005
Keywords
Sulfated chitosan; Lipid accumulation; Adipogenesis; 3T3-L1
Categories
Funding
- Ministry of Land, Transport and Maritime, Republic of Korea
Ask authors/readers for more resources
Inhibition of adipogenesis and lipid accumulation has a very crucial role to prevent obesity. Low molecular weight (LMW) chitosan is known to inhibit fat accumulation and adipogenesis. (N,O)-sulfated chitosan is a sulfation derivative of chitosan oligomers, and its anti-obesity effect is not yet reported. In this study, it has been reported that (N,O)-sulfated chitosan significantly decreased lipid accumulation, an indicator for adipogenesis, in differentiating 3T3-L1 preadipocyte cells. Furthermore, mRNA expressions and protein levels of key adipogenic markers such as peroxisome prolifetor-activated receptor (PPAR)-gamma and CCAAT-enhancer binding protein (C/EBP)-alpha were considerably decreased by (N,O)-sulfated chitosan treatment. As a consequence, sulfation of LMWC remarkably increased its effect of adipogenesis inhibition, adding (N,O)-sulfated chitosan high potential to be utilized as a bioactive agent in food and pharmaceutical industry. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available