Journal
CARBOHYDRATE POLYMERS
Volume 83, Issue 3, Pages 1169-1173Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.09.026
Keywords
Antibacterial activity; Water-soluble; O-Fumaryl-chitosan
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Funding
- fund for 863 Project [2007AA100401]
- National Natural Science Funds of China [20876068]
- State key Laboratory of Food Science and Technology [SKLF-MB-200805]
- Fund Project for Transformation of Scientific and Technological Achievements of Jiangsu Province [BA2009082]
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A novel water-soluble chitosan derivative, O-fumaryl-chitosan (OFCS), was prepared by using the selective partial acylation of chitosan and fumaric acid in the presence of H2SO4. The chemical structure and physical properties of OFCS were characterized by FTIR, H-1 NMR, C-13 NMR, and TG techniques. Our results showed that the degree of substitution (DS) for the chitosan derivatives was from 0.07 to 0.48 and the prepared derivatives had good solubility over a wide pH range, for example, the solubility of OFCS increased from 10.5 to 52.6 mg/ml as the DS increased. The antibacterial activity of chitosan and OFCS was investigated against Escherichia coli and Staphylococcus aureus. The results indicated that the antibacterial activity of OFCS was much stronger than that of chitosan and it increased with increasing DS increasing. These findings suggest that the OFCS with a DS of 0.48 is preferable for use as a food preservative. (C) 2010 Elsevier Ltd. All rights reserved.
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