Journal
CARBOHYDRATE POLYMERS
Volume 85, Issue 3, Pages 629-637Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2011.03.029
Keywords
Taxifolin; Cyclodextrin; Inclusion complex; Characterization; Inclusion mode
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Funding
- NSFC [30860342]
- Natural Science Foundation of Yunnan Province [2010CD090, 2009cc017]
- Opening Foundation of the State Key Laboratory of Elemento-Organic Chemistry of Nankai University [0704, 0815]
- Natural Science Foundation of Yunnan Education Department [2010Y429]
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The inclusion complexation behavior, characterization and binding ability of taxifolin with native cyclodextrin (alpha-, beta-, or gamma-CD) and its derivative hydroxypropyl-beta-cyclodextrin (HP beta CD) were investigated in both solution and the solid state by means of XRD, DSC, SEM, H-1 and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of taxifolin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the taxifolin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products. (C) 2011 Elsevier Ltd. All rights reserved.
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