Journal
CARBOHYDRATE POLYMERS
Volume 82, Issue 4, Pages 1297-1305Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.07.013
Keywords
Gelatin; Carboxymethyl chitosan; Hydrogel; Radiation crosslinking; Wound healing
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Funding
- State Key Development Program for Basic Research of China [2007CB936103]
- Peking University Interdisciplinary and Emerging Disciplines Research Foundation [PKUJC2009001]
- Peking University
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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A series of hydrogels were fabricated from an aqueous solution of gelatin and carboxymethyl chitosan (CM-chitosan) by radiation-induced-crosslinking at ambient temperature. Several physicochemical and biological properties of the hydrogels were investigated to evaluate their potential as wound healing materials. By increasing the CM-chitosan content in the hybrid hydrogels, their swelling ability increased significantly, while the compressive modulus decreased. The miscibility between gelatin and CM-chitosan molecules led to a semi-interpenetrate network after crosslinking. Observed by SEM, scaffolds with a homogeneous interconnected pore structure were obtained after lyophilizing the hydrogels. The enzyme degradation rate of the hydrogels was controlled by adjusting the procedure, which could be matched to the healing rate of the wound. Furthermore, the gelatin/CM-chitosan hydrogels promoted cell attachment and rapid growth of fibroblasts on the material. Due to the high water absorption capacity, a similar compressive modulus with soft tissue, controllable biodegradation, and excellent biocompatibility, the gelatin/CM-chitosan hybrid hydrogels have potential as skin scaffolds and wound healing materials. (C) 2010 Elsevier Ltd. All rights reserved.
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