Journal
CARBOHYDRATE POLYMERS
Volume 82, Issue 2, Pages 316-322Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.04.068
Keywords
Chitosan; Crosslinking; Sustained release; Poloxamer gel; Insulin delivery; Nasal drug delivery
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Funding
- National Science Council of the Republic of China, Taiwan [96-2221-E-224-077-MY3, 98-2221-E-224-009-MY2]
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This investigation examines the in vitro release of insulin in new thermo-response P-CS/GA/Gly gels, in which a chitosan (CS), crosslinked using glutaraldehyde (GA), interpenetrates Poloxamer (P) gels, and glycine (Gly) is further added to inhibit the crosslinking reactions of GA. The delivery of insulin by nasally administering P-CS/GA/Gly gels in diabetic rats was also examined. The release of insulin from P-CS/GA/Gly gels was significantly sustained (P<0.01) for about six times longer than release from P gels. The mechanisms of the release of insulin from the gels were consistent with a Fickian diffusion model. The nasal administering of insulin using P-CS/GA/Gly gels in diabetic rats is associated with a greatly prolonged hyperglycemic effect and a pharmacological efficiency (involving the maintenance of the lowest possible blood glucose levels (C-min, 55.5 +/- 2.8% of original values, n=6) for 3h, with a pharmacological efficiency of 18.0 +/- 1.8% (n= 6)) that significantly exceeded those achieved using other gels. (C) 2010 Elsevier Ltd. All rights reserved.
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