Journal
CARBOHYDRATE POLYMERS
Volume 81, Issue 2, Pages 340-347Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.02.028
Keywords
Cell migration; Cell adhesion; Cell spreading; Ginseng pectin; Homogalacturonan; Rhamnogalacturonan 1
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Funding
- National Natural Science Foundation of China [30670478, 30973857]
- Natural Science Foundation of Jilin Province [20070710]
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In this paper, ginseng pectin (WGPA) was fractionated and two new fractions were characterised. Nine fractions, including seven characterised in our previous paper, were tested for their effects on cell migration. The HG-domain rich pectins caused significant inhibition on cell migration. The order of the inhibitory effects is WGPA-1-HG < -2-HG < -3-HG < -4-HG. At 0.015 mg/ml, WGPA-3-HG significantly inhibited L-929 cell migration. WGPA-3-RG and -4-RG, containing both HG- and RG-1-domains, showed a slightly stronger inhibition than the HG-domain rich fractions. WGPA-N. WGPA-1-RG and -2-RG, containing no, trace or minor HG and RG-1 domains, showed less effects on cell migration. The inhibitory effect of ginseng pectic polysaccharides was related to GalA content (HG domain) and Rha content (RG-1 domain). The effect is probably mediated through decreasing cell adhesion and cell spreading. (C) 2010 Elsevier Ltd. All rights reserved.
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