Journal
CARBOHYDRATE POLYMERS
Volume 80, Issue 2, Pages 498-503Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.12.013
Keywords
Chitosan-graft-polycaprolactone; One-step synthesis; Biomaterials; Methanesulfonic acid; Brush-like polycations
Categories
Funding
- Chinese Ministry of Science and Technology [2007CB936104, 2009CB930300]
- Shanghai Municipality Commission for Special Project of Nanometer Science and Technology [0852nm03700, 0952nm05300]
- Shanghai Municipality Commission for Non-governmental International Corporation Project [09540709000]
Ask authors/readers for more resources
One-step approach was developed to synthesize amino-reserved chitosan-graft-polycaprolactone (CS-g-PCL) by grafting epsilon-CL oligomers onto the hydroxyl groups of CS via ring-opening polymerization by using methanesulfonic acid as solvent and catalyst. The controllable grafting content of PCL within CS-g-PCL provided the possibility to manipulate the biodegradation rate, hydrophilicity, and hence the cytotoxicity of CS-g-PCL. As a result, the specimen synthesized from the feed molar ratio of glucosamine units in CS vs. epsilon-CL as 1:12 showed equivalent cytotoxicity to the neat CS and PCL against KB cell line, and the cell viability was almost close to 100%. In addition, CS-g-PCL exhibited good solubility in organic solvents, facilitating formation of PCL/CS-g-PCL blend nanofibers via electrospinning with the use of DMF/CHCl3 as solvent. Owing to the enhanced cellular attachment results from cationic amino groups, it is promising that these copolymers are ideal substances for developing drug carriers and tissue engineering scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available