Journal
CARBOHYDRATE POLYMERS
Volume 80, Issue 3, Pages 733-739Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.12.019
Keywords
Homogeneous synthesis; Chitosan; Hydroxyl; Photochemistry; Cell adhesion
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Funding
- National Natural Science Foundation of China [20876018, 20736006]
- Chinese Academy of Sciences [KJCX2.YW.M02, KJCX2-YW-210-02]
- Scientific Research Foundation for Returned Scholars, Ministry of Education of China
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A novel homogeneous synthesis route was presented to produce RGD-containing peptide modified chitosan (CTS) with purpose of improving cell adhesion and growth. Bifunctional photosensitive crosslinker, Sulfo-SANPAH, was used to link cell adhesive peptide GRGDY and CTS under controlled condition. The synthesis process was proved by FTIR, MALDI-TOF MS and H-1 NMR analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of CTS were prior: to amino groups for nucleophilic reaction with Sulfo-SANPAH. Moreover, cell adhesion and proliferation were evaluated for GRGDY grafted CTS. The results showed that GRGDY grafted CTS formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.
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