Journal
CARBOHYDRATE POLYMERS
Volume 78, Issue 4, Pages 731-737Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.06.010
Keywords
Composite hydrogel bead; pH-sensitive; Controlled release; Diclofenac sodium
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Funding
- Western Action Project of CAS [KGCX2-YW-501]
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A series of pH-sensitive composite hydrogel beads composed of chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate (CTS-g-PAA/APT/SA) was prepared as drug delivery matrices crosslinked by Ca2+ owing to the ionic gelation of SA. The structure and surface morphology of the composite hydrogel beads were characterized by FTIR and SEM, respectively. pH-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. The results showed that the composite hydrogel beads had good pH-sensitivity. The cumulative release ratios of diclofenac sodium (DS) from the composite hydrogel beads were 3.76% in pH 2.1 solution and 100% in pH 6.8 solutions within 24h, respectively. However, the cumulative release ratio of DS in pH 7.4 solution reached 100% within 2 h. The DS cumulative release ratio reduced with increasing APT content from 0 to 50 wt%. The drug release was swelling-controlled at pH 6.8. (C) 2009 Elsevier Ltd. All rights reserved.
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