Journal
CARBOHYDRATE POLYMERS
Volume 78, Issue 3, Pages 439-443Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.04.030
Keywords
Quaternized chitosans; Antioxidant activity; Group electronegativity
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Funding
- key technology research and development programme of Shandong Province [2007GG2QT06020]
- Chinese Academy of Sciences
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Various quaternized chitosans (QCSs) were synthesized according to previous method. Their reducing power and antioxidant potency against hydroxyl radicals ((OH)-O-center dot) and hydrogen peroxide (H2O2) were explored by the established systems in vitro. The QCSs exhibited markedly antioxidant activity, especially TCEDMCS, whose IC50 on hydroxyl radicals was 0.235 mg/mL. They showed 65-80% scavenging effect on hydrogen peroxide at a dose of 0.5 mg/mL. Generally, the antioxidant activity decreased in the order TCEDMCS > TBEDMCS > EDMCS > PDMCS > IBDMCS > Chitosan. Furthermore, the order of their (OH)-O-center dot and H2O2 scavenging activity was consistent with the electronegativity of different substituted groups in the QCSs. The QCSs showed much stronger antioxidant activity than that of chitosan may be due to the positive charge density of the nitrogen atoms in QCSs strengthened by the substituted groups. (C) 2009 Elsevier Ltd. All rights reserved.
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