Journal
CARBOHYDRATE POLYMERS
Volume 76, Issue 3, Pages 368-373Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2008.10.025
Keywords
Chitosan; Enzymatic degradation; Nanoparticles; Insulin; Pulmonary administration; Hypoglycemic effect
Categories
Funding
- National Basic Research Program of China [2009CB930300]
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Low-molecular-weight chitosan (LMWC) was obtained by enzymatic degradation and ultrafiltration separation. LMWC nanoparticles with LMWC having 20 kDa weight average molecular weight (M-w) were then prepared by solvent evaporation method. The resultant nanoparticles were spherical with a narrow particle size distribution. LMWC nanoparticles loaded with insulin as a model drug were prepared. The average entrapment efficiency of insulin could reach up to 95.54%. The in vitro drug release profiles from the nanoparticles showed an initial burst of release in the first 2 h. followed by zero order release kinetics. In vivo pharmacodynamics of chitosan nanoparticles containing insulin showed that the nanoparticles showed some whypoglycemic activity. Compared with an insulin solution, a relative bioavailability of 0.737 was observed for four times the dosage of insulin in the chitosan nanoparticles after pulmonary administration. (C) 2008 Elsevier Ltd. All rights reserved.
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