Journal
CARBOHYDRATE POLYMERS
Volume 76, Issue 2, Pages 255-260Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2008.10.015
Keywords
Chitosan hydrogel; Chitosan/gelatin membranes; XRD studies; Thermal studies; Mechanical properties
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Funding
- MEXT (Ministry of Education, Culture, Sports, Science and Technology), 2005-2009
- JSPS FY 2005-2006 [17.05405]
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Chitin and chitosan are novel biomaterials. The novel chitosan/gelatin membranes were prepared using the suspension of chitosan hydrogel mixed with gelatin. The prepared chitosan/gelatin membranes were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), mechanical, swelling, and thermal Studies. The morphology of these chitosan/gelatin membranes was found to be very smooth and homogeneous. The XRD studies showed that the chitosan/gelatin membranes have good compatibility and interaction between the chitosan and gelatin. The stress and elongation of chitosan/gelatin membranes on wet condition showed excellent when the mixture ratio of gelatin was 0.50. The prepared chitosan/gelatin membranes showed good swelling, mechanical and thermal properties. Cell adhesion studies were also carried out using human MG-63 osteoblast-like cells. The cells incubated with chitosan/gelatin membranes for 24 h were capable of forming cell adhesion. Thus the prepared chitosan/gelatin membranes are bioactive and are suitable for cell adhesion suggesting that these membranes can be used for tissue-engineering applications. Therefore, these novel chitosan/gelatin membranes are useful for biomedical applications. (C) 2008 Elsevier Ltd. All rights reserved.
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