Journal
CARBOHYDRATE POLYMERS
Volume 73, Issue 2, Pages 261-264Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2007.11.025
Keywords
water-soluble chitosan; N-monocarboxymethylchitosan; N,N '-dicarboxymethylchitosan; osteogenesis agent; chelating agent
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Fully substituted N,N'-dicarboxymethylchitosan was obtained by the alkylation of chitosan at pH 8-8.5 and 90 degrees C using a monochloroacetic acid:chitosan weight ratio of 4:1. The water-soluble derivative is a chelating agent suitable for treatment of osteogenis or other applications involving chelation. (C) 2007 Elsevier Ltd. All rights reserved.
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