Journal
FEBS JOURNAL
Volume 272, Issue 18, Pages 4576-4589Publisher
WILEY
DOI: 10.1111/j.1742-4658.2005.04864.x
Keywords
PARP; tankyrase; poly(ADP-ribose); DNA damage; DNA repair; genomic instability; centrosome; centromere; telomeres; mitotic spindle
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One of the most drastic post-translational modification of proteins in eukaryotic cells is poly(ADP-ribosyl)ation, catalysed by a family enzymes termed poly(ADP-ribose) polymerases (PARPs). In the human genome, 18 different genes have been identified that all encode PARP family members. Poly(ADP-ribose) metabolism plays a role in a wide range of biological structures and processes, including DNA repair and maintenance of genomic stability, transcriptional regulation, centromere function and mitotic spindle formation, centrosomal function, structure and function of vault particles, telomere dynamics, trafficking of endosomal vesicles, apoptosis and necrosis. In this article, the most recent advances in this rapidly growing field are summarized.
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