Journal
ACS CHEMICAL BIOLOGY
Volume 10, Issue 1, Pages 95-108Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb500846u
Keywords
-
Categories
Funding
- National Institutes of Health (NIH) [GM059785-15/P250VA]
- Molecular and Applied Nutrition Training Program (NIH) [5T32DK007665-22]
Ask authors/readers for more resources
Histone post-translational modifications regulate transcription and other DNA-templated functions. This process is dynamically regulated by specific modifying enzymes whose activities require metabolites that either serve as cosubstrates or act as activators/inhibitors. Therefore, metabolism can influence histone modification by changing local concentrations of key metabolites. Physiologically, the epigenetic response to metabolism is important for nutrient sensing and environment adaption. In pathologic states, the connection between metabolism and histone modification mediates epigenetic abnormality in complex disease. In this review, we summarize recent studies of the molecular mechanisms involved in metabolic regulation of histone modifications and discuss their biological significance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available