Journal
CANCER TREATMENT REVIEWS
Volume 74, Issue -, Pages 49-60Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2018.08.006
Keywords
Interventional oncology; Immune checkpoint inhibitor; Immunotherapy; Synergistic effect
Categories
Funding
- National Basic Research Program of China (973 Program) [2013CB733800, 2013CB733803]
- Jiangsu Provincial Special Program of Medical Science [BL2013029]
- National Natural Science Foundation of China [81671795]
- Jiangsu Graduate Student Innovation Grant [KYZZ15_0066]
- Excellent Doctoral Dissertations Cultivation Fund from Southeast University
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Immune checkpoint inhibitors-based immunotherapy offers a new effective modality in the treatment of advanced malignancies. Considering the remarkable efficacy of immune checkpoint inhibitors in clinical trials, the FDA has approved a variety of immune checkpoint inhibitors for the treatment of advanced tumors. However, only limited patients with certain cancers can benefit from monotherapy of immune checkpoint inhibitors. Interventional therapy for cancer can not only destroy the primary tumors, but also regulate the immune system through different mechanisms, which provides a potential possibility for the combination of immune checkpoint inhibitors and Interventional modalities in cancer treatment. This article reviews the possible synergistic mechanisms of interventional therapy combined with immune checkpoint inhibitors and summarizes the research progress of the combined therapy in cancer treatment.
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