Journal
CANCER TREATMENT REVIEWS
Volume 39, Issue 6, Pages 602-609Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2012.12.013
Keywords
Mantle cell lymphoma; First line therapy; Conventional therapy; Intensive therapy
Categories
Funding
- Roche
- Cellgene
- Jansen
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Mantle cell lymphoma (MCL) is one of the lymphomas with the worse prognosis (median survival 3-5 years) as it has an aggressive evolution and at the same time is incurable. Biologically it is characterized by the t(11;14)(q13;q32) translocation leading to overexpression of cyclin D1. This review focuses on a number of controversial issues in the management of this disease, as how to stage patients with a disease which often has extranodal localizations, how to recognize the small subgroup of cases with an indolent course, which treatment is suggested for the young and fit or for the elderly, the role of CNS prophylaxis, rituximab maintenance and radiotherapy, the indications to allogeneic transplantation and the place of new active anti-lymphoma drugs. (C) 2013 Elsevier Ltd. All rights reserved.
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