Journal
CANCER TREATMENT REVIEWS
Volume 38, Issue 7, Pages 868-876Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2012.06.008
Keywords
Apoptosis; Gene therapy; Cancer; Targeted therapy
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The unraveling of cellular apoptosis machinery provides novel targets for cancer treatment, and gene therapy targeting this suicidal system has been corroborated to cause inflammation-free autonomous elimination of neoplastic cells. The apoptotic machinery can be targeted by introduction of a gene encoding an inducer, mediator or executioner of apoptotic cell death or by inhibition of anti-apoptotic gene expression. Strategies targeting cancer cells, which are achieved by selective gene delivery, specific gene expression or secretion of target proteins via genetic modification of autologous cells, dictate the outcome of apoptosis-based cancer gene therapy. Despite so far limited clinical success, gene therapy targeting the apoptotic machinery has great potential to benefit patients with threatening malignancies provided the availability of efficient and specific gene delivery and administration systems. (C) 2012 Elsevier Ltd. All rights reserved.
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