Journal
CANCER TREATMENT REVIEWS
Volume 38, Issue 2, Pages 101-110Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2011.04.014
Keywords
Minimal residual disease; Cancer stem cells; Circulating tumor cells; Disseminated tumor cells/micrometastasis
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Despite recent advances in prevention, screening, molecular characterization, and treatment, cancer evolution is still associated with late local, regional, or metastastic recurrence, even in early stages. Residual tumor cells can persist locally as cancer stem cells, in the blood flow as circulating tumor cells, and in distant organs as disseminated tumor cells or micrometastasis, defining three faces of minimal residual disease. Definition, preclinical models and clinical implications of these patterns will be detailed, with emphasis on overlaps and therapeutic implications, to determine whether minimal residual disease is only an old concept currently revisited, or a major shift in cancer paradigm. (C) 2011 Elsevier Ltd. All rights reserved.
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