Journal
CANCER TREATMENT REVIEWS
Volume 35, Issue 4, Pages 309-321Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2008.12.001
Keywords
Cancer; Targeted therapy; Molecular imaging; Functional imaging
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The development of targeted therapies is a major breakthrough in the treatment of cancer. By evoking necrosis and cavitation, evaluation based on tumour size alone, as is done in the RECIST criteria, is no longer an adequate method. New molecular and functional imaging techniques are developed. This review focuses on the use of new imaging modalities for the evaluation of treatment response of pathway based targeted therapies. First, the basic principles of functional and molecular imaging modalities are briefly discussed. Thereafter, their clinical application in targeted therapies is correlated to the underlying biological mechanism. in this way, the best method for response evaluation for a new agent can be identified. (C) 2008 Elsevier Ltd. All rights reserved.
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