Journal
CANCER SCIENCE
Volume 109, Issue 12, Pages 3671-3678Publisher
WILEY
DOI: 10.1111/cas.13802
Keywords
cancer; inflammation; lipid mediator; sphingosine-1-phosphate; tumor microenvironment
Categories
Funding
- Susan G. Komen for the Cure [IIR12222224]
- National Cancer Institute [R01CA160688]
- Japan Society for the Promotion of Science [JP16K15610, JP18K19576]
- NATIONAL CANCER INSTITUTE [R01CA160688] Funding Source: NIH RePORTER
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Many inflammatory mediators are involved in the process of carcinogenesis and cancer progression. In addition to cytokines and chemokines, lipid mediators have recently attracted attention as signaling molecules associated with inflammatory diseases. Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival and migration, immune cell recruitment, angiogenesis and lymphangiogenesis. S1P also plays a significant role in inflammation and cancer. The gradation of S1P concentration in the blood, lymph and tissue regulates lymphocyte trafficking, an important component of inflammation. Furthermore, cancer cells produce elevated levels of S1P, contributing to the tumor microenvironment and linking cancer and inflammation. Future technological advances may reveal greater detail about the mechanisms of S1P regulation in the tumor microenvironment and the contribution of S1P to cancer progression. Considering the critical role of S1P in linking inflammation and cancer, it is possible that the S1P signaling pathway could be a novel therapeutic target for cancers with chronic inflammation.
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