Journal
FEBS JOURNAL
Volume 272, Issue 1, Pages 16-27Publisher
WILEY
DOI: 10.1111/j.1432-1033.2004.04407.x
Keywords
-
Categories
Ask authors/readers for more resources
Why are there so many dimeric proteins and enzymes? While for heterodimers a functional explanation seems quite reasonable, the case of homodimers is more puzzling. The number of homodimers found in all living organisms is rapidly increasing. A thorough inspection of the structural data from the available literature and stability (measured from denaturation-renaturation experiments) allows one to suggest that homodimers can be divided into three main types according to their mass and the presence of a (relatively) stable monomeric intermediate in the folding-unfolding pathway. Among other explanations, we propose that an essential advantage for a protein being dimeric, may be the proper and rapid assembly in the cellular milieu.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available