Journal
CANCER SCIENCE
Volume 103, Issue 1, Pages 150-153Publisher
WILEY
DOI: 10.1111/j.1349-7006.2011.02106.x
Keywords
-
Categories
Funding
- New Energy and Industrial Technology Development Organization (NEDO)
- Grants-in-Aid for Scientific Research [22790370] Funding Source: KAKEN
Ask authors/readers for more resources
A patient with pulmonary metastasis of colon cancer was treated with artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP) of MAGE-A4 cancer antigen. The patient was vaccinated with MAGE-A4-H/K-HELP combined with OK432 and Montanide ISA-51. There were no severe side-effects except for a skin reaction at the injection site. MAGE-A4-H/K-HELP induced MAGE-A4-specific Th1 and Tc1 immune responses and the production of MAGE-A4-specific complement-fixing IgG antibodies. Tumor growth and carcinoembryonic antigen tumor marker were significantly decreased in the final diagnosis. This is the first report that artificially synthesized MAGE-A4-H/K-HELP induces Th1-dependent cellular and humoral immune responses in a human cancer patient. (Cancer Sci 2012; 103: 150-153)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available