Optical fiber-based on-line UV/Vis spectroscopic monitoring of chemical reaction kinetics under high pressure in a capillary microreactor

With a miniaturized (3 mu L volume) fiber-optics based system for on-line measurement by UV/Vis spectroscopy, the reaction rate constants ( at different pressures) and the activation volumes ( DV?) were determinined for a nucleophilic aromatic substitution and an aza Diels-Alder reaction in a capillary microreactor.