Journal
CANCER SCIENCE
Volume 100, Issue 4, Pages 572-579Publisher
WILEY
DOI: 10.1111/j.1349-7006.2009.01103.x
Keywords
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Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Japanese Foundation for Multidisciplinary Treatment of Cancer
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The size of anticancer agent-incorporating micelles can be controlled within the diameter range of 20-100 nm to ensure that they do not penetrate normal vessel walls. With this development, it is expected that the incidence of drug-induced side-effects may be decreased owing to the reduced drug distribution in normal tissue. Micelle systems can also evade non-specific capture by the reticuloendothelial system because the outer shell of a micelle is covered with polyethylene glycol. Consequently, a polymer micelle carrier can be delivered selectively to a tumor by utilizing the enhanced permeability and retention effect. Moreover, a water-insoluble drug can be incorporated into polymer micelles. Presently, several anticancer agent-incorporating micelle carrier systems are under preclinical and clinical evaluation. Furthermore, nucleic acid-incorporating micelle carrier systems are also being developed. (Cancer Sci 2009; 100: 572-579)
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