Journal
CANCER SCIENCE
Volume 100, Issue 7, Pages 1158-1165Publisher
WILEY
DOI: 10.1111/j.1349-7006.2009.01178.x
Keywords
-
Categories
Funding
- Japan Science and Technology Agency
- Tohoku University 'Evolution' program
- Takeda Science Foundation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Uehara Memorial Foundation
Ask authors/readers for more resources
Loss or gain of chromosomes is associated with many cancer cells. This property, called chromosome instability, might arise from a lesion in the chromosome segregation machinery. Essential for chromosome segregation are the proper connection of microtubules to kinetochores, and the synchronous segregation of sister chromatids in anaphase. Accuracy of these processes is ensured by two sophisticated machineries called the correction mechanism and the spindle assembly checkpoint. Here we outline the current understanding of the underlying mechanisms, and highlight recent challenging experiments to address how chromosome segregation failure might relate to tumorigenesis. Understanding these mechanisms may lead to the discovery of new and improved anticancer therapies. (Cancer Sci 2009; 100: 1158-1165)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available