Unprecedented asymmetric induction through configurationally stable lithium N-(alpha-methylbenzyl) phosphinamides. A new entry to enantiomerically pure gamma-aminophosphinic acids and esters

The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral gamma-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown.