Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 34, Pages 4279-4281Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b506986f
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Incorporation of a single pyrene-functionalized 29-amino-alpha-L-LNA monomer X into short DNA strands induces extraordinarily high binding affinity towards complementary DNA (up to 16 degrees C increase per modification), whereas labile duplexes, suitable as probes for targeting of double stranded DNA, are formed upon positioning of two monomers X in an interstrand +1 zipper motif.
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