4.7 Article

In situ hybridization of PNA/DNA studied label-free by electrochemical impedance spectroscopy

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 23, Pages 2969-2971

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b419425j

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The in situ hybridization kinetics of label-free DNA on mixed monolayers of peptide nucleic acid (PNA) and 6-mercapto-1-hexanol (MCH) on Au electrodes was investigated by electrochemical impedance spectroscopy (EIS) and used to discriminate the fully complementary DNA from the single-base mismatched hybrids.

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