Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 20, Pages 2597-2599Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b501527h
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Substrate engineered, achiral carboxylic acid derivative 2 was biohydroxylated with various mutants of cytochrome P450 BM-3 to give two out of the four possible diastereoisomers in high de and ee. The BM-3 mutants exhibit up to 9200 total turnovers for hydroxylation of the engineered substrate, which without the protecting group is not transformed by this enzyme.
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