Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 12, Pages 1560-1562Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b418106a
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The first enantioselective synthesis of the anti-Helicobacter pylori agent (+)-spirolaxine methyl ether has been carried out in a convergent fashion by heterocycle- activated Julia olefination of a spiroacetal-containing sulfone fragment with a phthalide-containing aldehyde fragment. The total synthesis of (+)-spirolaxine methyl ether establishes the absolute stereochemistry of the natural product to be (3R, 2 '' R, 5 '' R, 7 '' R).
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