Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 17, Pages 3857-3859Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.05.119
Keywords
mycobacteria; butyrolactones
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Funding
- NIAID NIH HHS [AI 054842] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI054842] Funding Source: NIH RePORTER
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The synthesis and antimyco bacterial activity of a series of alpha-methylene-gamma-butyrolactones based on the natural product protolichesterinic acid are described. Compounds 9-12 bearing an allylamide group at the C-4 position showed improved activity with MICs in the range of 6.25-12.5 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.
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