Journal
AMERICAN JOURNAL OF ROENTGENOLOGY
Volume 185, Issue 3, Pages 763-767Publisher
AMER ROENTGEN RAY SOC
DOI: 10.2214/ajr.185.3.01850763
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OBJECTIVE. Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION. Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.
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