Journal
NUCLEIC ACIDS RESEARCH
Volume 33, Issue 12, Pages 3845-3854Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gki701
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Funding
- NATIONAL CANCER INSTITUTE [R37CA042471, R01CA042471] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM056492] Funding Source: NIH RePORTER
- NCI NIH HHS [CA42471, R01 CA042471, R37 CA042471] Funding Source: Medline
- NIGMS NIH HHS [R01 GM056492, GM056492] Funding Source: Medline
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Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays an important role in a variety of infectious and autoimmune disorders. Its transcription is regulated in a stimulus- and cell-type-specific manner via the recruitment of distinct DNA/activator complexes forming secondary structures or enhanceosomes. NFATp, a member of the nuclear factor of activated T cells (NFAT) family of transcription factors, plays a critical role in TNF gene regulation under a variety of conditions. In this study, we show that NFAT5, the most recently described NFAT family member, binds to the TNF promoter in a manner distinct from other NFAT proteins and is a key mediator in the activation of TNF gene transcription during hypertonic stress alone.
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