Journal
MOVEMENT DISORDERS
Volume 20, Issue 1, Pages 75-77Publisher
WILEY
DOI: 10.1002/mds.20283
Keywords
paroxysmal kinesigenic choreoathetosis; topiramate; treatment
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We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow-up period ranged from 8 months to 2 years. All of the patients became attack-free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect. (C) 2004 Movement Disorder Society
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